Well, NuPIC is not what I would call “lightweight”. It can be difficult to install on remote environments, but docker helps.
I don’t think any of these HTM projects are in a place right now where it makes sense to build hierarchies out of compute nodes (although I see this as the way of the future). See H is for Hierarchy, but where is it? for details there.
If you are talking about prediction, here are a couple of things you should be aware of.