# Some ISI problem?

**URL:** <https://discourse.numenta.org/t/some-isi-problem/6642>\
**Category:** General Neuroscience\
**Tags:** evolution\
**Created:** [September 30, 2019, 11:35am UTC](https://discourse.numenta.org/t/some-isi-problem/6642 "2019-09-30T11:35:58Z")\
**Posts on this page:** 1\
**Page:** 2

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**Author:** ![mthiboust](https://yyz2.discourse-cdn.com/flex030/user_avatar/discourse.numenta.org/mthiboust/32/4509_2.png) [@mthiboust](https://discourse.numenta.org/u/mthiboust)\
**Post date:** [October 2, 2019, 11:59am UTC](https://discourse.numenta.org/t/some-isi-problem/6642/21 "2019-10-02T11:59:58Z")

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When I first read about DNA methylation for memory storage in the nervous system, I also found it silly… because we are so used to the classic principle of synaptic learning.

But this Nature article seems reliable and the author’s deep background in hippocampus & synaptic plasticity makes it even more serious:  
[https://scholar.google.co.uk/scholar?as\_q=&num=10&btnG=Search+Scholar&as\_epq=&as\_oq=&as\_eq=&as\_occt=any&as\_sauthors=“Wickliffe%20C.+Abraham”&as\_publication=&as\_ylo=&as\_yhi=&as\_allsubj=all&hl=en](https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Wickliffe%20C.+Abraham%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en)

So, I think it is worth paying attention to this provocative idea, who knows…

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