Are place cells just memory cells?

Are place cells just memory cells?

Memory compression leads to spatial tuning and history dependence


The observation of place cells has suggested that the hippocampus plays a special role in encoding spatial information. However, place cell responses are modulated by several non-spatial variables, and reported to be rather unstable. Here we propose a memory model of the hippocampus that provides a novel interpretation of place cells consistent with these observations. We hypothesize that the hippocampus is a memory device that takes advantage of the correlations between sensory experiences to generate compressed representations of the episodes that are stored in memory. A simple neural network model that can efficiently compress information naturally produces place cells that are similar to those observed in experiments. It predicts that the activity of these cells is variable and that the fluctuations of the place fields encode information about the recent history of sensory experiences. Place cells may simply be a consequence of a memory compression process implemented in the hippocampus.


I will add a note to this: most of the research into the contents of the HC/EC complex has been on spatial tasks such as where a critter is in a cage. It should come as no surprise that what the end up seeing is something related the the perception of space.

Different tasks should reveal others aspects of the episodic memories processed there.

I suggest that social interactions should reveal very different types of cells than the usual place/border/vector/… spatial mappings.

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