I think you are right: HTM/CLA ignores most details in the cortical column. High-level considerations can be modeled there. But at lower levels, many details (such as bursting dynamics, neuromodulation, etc…) aren’t considered yet. Nevertheless, is the step in the right direction. I think that is the cornerstone over many other pieces will be built.
In any case, my point was about neuroscience. The structure of the cortex is regular, and although somehow you can “define” separate regions [1], I think most of that is a consequence of the “sensory” input [2]. Ergo, if the cortical columns are regular, the only prior there is the “base” algorithm, which is agnostic to the data.
[1] M. F. Glasser, T. S. Coalson, E. C. Robinson, C. D. Hacker, J. Harwell, E. Yacoub, K. Ugurbil, J. Andersson, C. F. Beckmann, M. Jenkinson, S. M. Smith, and D. C. Van Essen, “A multi-modal parcellation of human cerebral cortex,” Nature , vol. 536, no. 7615, pp. 171–178, 2016.
[2] N. V De Marco GarcĂa, R. Priya, S. N. Tuncdemir, G. Fishell, and T. Karayannis, “Sensory inputs control the integration of neurogliaform interneurons into cortical circuits,” Nat. Neurosci. , vol. 18, no. 3, pp. 393–401, Mar. 2015.