Difference between brain hemispheres

I was speaking to the point:

“So this brings the question as to the difference between the individual cortical columns in the left vs the right brain. Are there differences? If not, what is causing the hemispheres to be thinking differently?”

Left or right can perform the functions, it is up to connectivity. I don’t think that there is anything special in the local construction that forces a section of cortex to be spatial or a speech center.