New Science paper from Mayank Mehta’s group showing evidence for dendritic spikes in behaving animals, twice as many during behavior than during sleep. Not surprising for the HTM-inclined, these would presumably represent either prediction events that don’t lead to active cells, and/or multiple segments simultaneously predicting. I would be very interested to see a synaptic plasticity study measuring STDP with respect to presynaptic spikes, postsynaptic dendritic spikes, and postsynaptic somatic spikes.
Also very interesting, in addition to the large number of dendritic spikes, the study reports large amplitude slow current fluctuations in the dendritic trees, and Mehta speculates this could be evidence of analog computation. What do you think? Evidence for temporal pooling?
 Moore et al., “Dynamics of cortical dendritic membrane potential and spikes in freely behaving rats”. http://science.sciencemag.org/content/early/2017/03/08/science.aaj1497